Increased iron in the dentate nucleus of patients with Friedreich's ataxia
- 1 July 1999
- journal article
- research article
- Published by Wiley in Annals of Neurology
- Vol. 46 (1) , 123-125
- https://doi.org/10.1002/1531-8249(199907)46:1<123::aid-ana19>3.0.co;2-h
Abstract
Friedreich's ataxia (FA) is the most frequently inherited ataxia. To test the hypothesis that iron is increased in the cerebellum of patients with FA, we developed a multigradient echo magnetic resonance sequence for the three-dimensional imaging of brain iron-induced contrast. Relaxation rate (R2*) values in the unaffected globus pallidus were equal in FA patients and controls, although R2* values in the dentate nucleus of patients were significantly higher, which is most likely due to increased iron. Ann Neurol 1999;46:123–125Keywords
This publication has 19 references indexed in Scilit:
- Frataxin is Reduced in Friedreich Ataxia Patients and is Associated with Mitochondrial MembranesHuman Molecular Genetics, 1997
- Regulation of Mitochondrial Iron Accumulation by Yfh1p, a Putative Homolog of FrataxinScience, 1997
- Friedreich's Ataxia: Autosomal Recessive Disease Caused by an Intronic GAA Triplet Repeat ExpansionScience, 1996
- Early‐onset ataxia with cardiomyopathy and retained tendon reflexes maps to the friedreich's ataxia locus on chromosome 9qAnnals of Neurology, 1995
- Late-Onset Friedreich's AtaxiaArchives of Neurology, 1993
- Mapping of mutation causing Friedreich's ataxia to human chromosome 9Nature, 1988
- The neuropathology of “typical” Friedreich's ataxia in QuebecCanadian Journal of Neurological Sciences, 1984
- FRIEDREICH'S ATAXIA: A CLINICAL AND GENETIC STUDY OF 90 FAMILIES WITH AN ANALYSIS OF EARLY DIAGNOSTIC CRITERIA AND INTRAFAMILIAL CLUSTERING OF CLINICAL FEATURESBrain, 1981
- Pathology of the Heart in Friedreich's Ataxia: Review of the Literature and Report of One CaseCanadian Journal of Neurological Sciences, 1976
- Ueber degenerative Atrophie der spinalen HintersträngeVirchows Archiv, 1863