TMC-1 A, B, C and D, New Antibiotics of the Manumycin Group Produced by Streptomyces sp. Taxonomy, Production, Isolation, Physico-chemical Properties, Structure Elucidation and Biological Properties.
- 1 January 1996
- journal article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 49 (12) , 1212-1220
- https://doi.org/10.7164/antibiotics.49.1212
Abstract
Four new antitumor antibiotics, TMC-1 A, B, C and D were isolated from a fermentation broth of Streptomyces sp. A-230. Spectroscopic studies have shown that TMC-1 A to D were new members of the manumycin class of antibiotics. These antibiotics showed cytotoxic activities against various tumor cell lines in vitro.Keywords
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