Use of a Solid Phase Red Blood Cell Adherence Method for Pretransfusion Platelet Compatibility Testing
Open Access
- 1 July 1988
- journal article
- research article
- Published by Oxford University Press (OUP) in American Journal of Clinical Pathology
- Vol. 90 (1) , 63-68
- https://doi.org/10.1093/ajcp/90.1.63
Abstract
A solid phase red blood cell adherence method has been used for platelet antibody detection and crossmatching for refractory platelet recipients. Patient sera were first screened for HLA or platelet-specific antibodies, then crossmatched with potential apheresis platelet donors. The overall correlation of platelet crossmatch results with transfusion outcome was 97% in patients with no evidence of nonimmune platelet destruction. The solid phase red blood cell adherence method provided a feasible and effective alternative to HLA matching as a means of donor selection for refractory platelet recipients. The speed and simplicity of this method may allow most hospital laboratories to perform platelet antibody screening before routine platelet transfusions.Keywords
This publication has 11 references indexed in Scilit:
- Potential HLA‐matched platelet donor availability for alloimmunized patientsTransfusion, 1983
- AN ENZYME-LINKED IMMUNOSORBENT-ASSAY FOR PLATELET COMPATIBILITY TESTING1983
- A RADIOLABELED ANTIGLOBULIN-TEST FOR CROSSMATCHING PLATELET TRANSFUSIONS1983
- Serological studies in patients on platelet‐ and granulocyte‐substitution therapyBritish Journal of Haematology, 1982
- SELECTION OF DONOR PLATELETS FOR ALLOIMMUNIZED PATIENTS USING A PLATELET-ASSOCIATED IGG ASSAY1981
- LONG-TERM FOLLOW-UP OF PATIENTS WITH LEUKEMIA RECEIVING PLATELET TRANSFUSIONS - IDENTIFICATION OF A LARGE GROUP OF PATIENTS WHO DO NOT BECOME ALLOIMMUNIZED1981
- Platelet transfusion therapy. One-hour posttransfusion increments are valuable in predicting the need for HLA-matched preparationsJAMA, 1980
- HLA-MATCHED PLATELET TRANSFUSION THERAPY OF SEVERE APLASTIC-ANEMIA1978
- PLATELET TRANSFUSION THERAPY - OPTIMAL DONOR SELECTION WITH A COMBINATION OF LYMPHOCYTOTOXICITY AND PLATELET FLUORESCENCE TESTS1978
- Platelet Transfusions From HL-A Compatible Unrelated Donors to Alloimmunized PatientsAnnals of Internal Medicine, 1974