Triphenyltin chloride inhibits superoxide production by human neutrophils stimulated with a surface active agent
Open Access
- 12 December 1983
- journal article
- Published by Wiley in FEBS Letters
- Vol. 164 (2) , 251-254
- https://doi.org/10.1016/0014-5793(83)80296-8
Abstract
Treatment of human neutrophils with triphenyltin chloride (TPTCl)‐inhibited superoxide (O− 2) production stimulated with phorbol myristate acetate (PMA). TPTCl was more potent as inhibitor of O− 2 production than other phenyltin compounds. The O− 2 production by the xanthine oxidase—acetaldehyde system was not inhibited by TPTCl. This finding indicates that TPTCl does not itself react with O− 2. Furthermore, TPTCl did not influence the isolated NADPH oxidase at all, though O− 2 production of neutrophils stimulated with PMA in the presence of TPTCl was inhibited. These results indicate that TPTCl inhibits the activation process of the O− 2 generating system.Keywords
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