A STUDY OF THE RELATIONSHIP BETWEEN THE THYROID GLAND AND SEBUM SECRETION IN THE RAT

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Abstract
SUMMARY: Thyroidectomy of intact and castrated rats produced significant reductions in their rates of sebum secretion. Replacement therapy with thyroxine (T4) increased the rate of sebum secretion of the castrated-thyroidectomized rats. Treatment with testosterone propionate also stimulated sebum secretion in castrated-thyroidectomized rats. When given together these two hormones had an additive effect on the rate of sebum secretion. Thyrotrophic hormone (TSH) stimulated sebum secretion in castrated-hypophysectomized, but not in thyroidectomized rats. It is concluded that TSH affects sebum secretion through its action on the thyroid, presumably by stimulation of T4 secretion.

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