THE ABSORPTION AND GLYCOGENIC ACTIVITY OF CORTISONE AND HYDROCORTISONE AFTER PARENTERAL ADMINISTRATION TO RATS

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Abstract
Rats were given single subcut. or intramusc. injns. of cortisone acetate (E Ac), cortisone alcohol (E Alc), hydrocortisone acetate (F Ac) and hydrocortisone alcohol (F Alc). Animals were sacrificed daily therafter for 4 days, and after 7 days. Analysis of the livers for glycogen and of the injn. sites for residual steroids yielded information on the rates of absorption and relative activities of the hormones. Of the 4 compounds injd., F Ac was the least rapidly absorbed, and in the quantities given, persisted to a high degree at the site of injn. for at least 7 days. F Alc was the most rapidly absorbed, only traces remaining at the injn. sites after 7 days. Absorption of the 4 compounds was more rapid after intramusc. than after subcut. admn. E Ac appeared to be from 1.5 to 2 times as active as E Alc per mg. absorbed. Subcut. deposits of E Ac, although relatively ineffective in promiting the deposition of liver glycogen 7 days after injn., were active when removed and reinjected.