Evaluation of a Nuclease-Resistant Derivative of Poly(I)·Poly(C) [Poly(ICLC)] as a Radioprotective Agent

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Abstract
I.m. injection of a stabilized poly(I).cntdot.poly(C) complex, composed of the 2 acids, poly-L-lysine and carboxymethylcellulose [poly(ICLC)], was radioprotective in mice when given in single or multiple doses before total-body irradiation. At low to moderately high dosages, LD50/30 values were increased significantly (P < 0.05), with a maximum dose-reduction factor of 1.25. Survival rates and weighted mean survival times were also significantly increased. Increased circulating levels of serum interferon proportional to poly(ICLC) concentration were not required at the time of irradiation for radioprotection. Poly(ICLC) had a slight stimulatory effect on the numbers of peripheral blood elements in irradiated mice.