THE FORMATION OF THYROXINE METABOLITES BY ESCHERICHIA COLI

Publisher Website
Google Scholar
Abstract
A "wild" strain of Escherichia coli was incubated with labelled and nonlabelled L-thyroxine. Chromatographic and elec-trophoretic studies demonstrated that several iodinated compounds were formed during incubation. One of the compounds seems fairly certainly to be tetra-iodothyroacetic acid (Tetrac, TA4), others may be tri-iodothyroacetic acid (Triac, TA3) and tetra-iodothyroformic acid (TFform4, Tetraform) but the identification of these substances requires further studies. An unknown compound stainable with diazotised sulphanilic acid and with a great mobility on chromatog- raphy was observed. The findings may have some bearing on the enterohepatic circulation of the thyroid hormones. The usefulness of microbial techniques in the elucidation of the tissue metabolism of thyroid hormones and in the preparation of thyroxine analogues is pointed out.

This publication has 0 references indexed in Scilit: