THE FATE OF AN INTRANEURAL INJECTION AS DEMONSTRATED BY THE USE OF RADIO-ACTIVE PHOSPHORUS

Open Access
Publisher Website
Google Scholar
Abstract
The exposed left sciatic nerve of nembutalized rabbits was injected after hemostasis with 0.05 ml. of P32 (as phosphoric acid) at 3 levels; "low" in the upper popliteal region, 4 cases; "midfemoral," 6 cases; "high" at the greater trochanter, 6 cases. Four controls were given 50-60 [mu]c of P32 intraven. Fortuitously, the injns. were either (a) the "cord-cerebrospinal fluid type" in which there was central spread along neural interfiber spaces into the spinal cord and the cerebrospinal fluid or (b) the "blood type" in which the fluid spread was sub-perineural and characterized by absorption into the blood stream. Trauma during injn. insures type (a). "Low" injns. yielded 1 type (a) and 3 type (b). "Midfemorals" were 2 type (a) and 4 type (b). "High" injns. penetrated the central nervous system, in 1 case as far as the basal ganglia, but did not affect the cerebrospinal fluid. Radioactive concns. were detected in the contralateral sciatic nerve, at levels comparable to the site of injn. in 8 of 13 cases.

This publication has 11 references indexed in Scilit: