An experimental enquiry into the nature of the substance in serum which influences phagocytosis

Abstract
In a previous communication it was shown that in certain immune sera, e. g ., in anti-staphylococcus, in anti-dysentery, and in anti-typhoid serum, there are present thermostable substances which, by their action, prepare the homologous organisms for phagocytosis. The thermostability in the case of these immune sera could be demonstrated by the use of Wright and Douglas’ method, whereas in the case of normal serum another method was, as a rule, necessary. In the case of the serum of the horse, however, it was pointed out that even by Wright and Douglas’ method the increase of phagocytosis, observed by using normal heated serum, was, as compared with salt solution, generally considerable. In view of certain experimental data and having regard to Ehrlich’s theory, the conclusion was arrived at that the thermostable substances of normal and immune sera were probably identical.

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