THE EQUALITY OF THE CHLORIDE SPACE AND THE EXTRACELLULAR SPACE OF RAT LIVER

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Abstract
The extracellular vol. (i.e., the vol. of the liver not occupied by hepatic cells) as detd. histologically was found to be quantitatively equal to the chloride space as detd. chemically. In a series of 14 rats, in which the cellular constituents (glycogen, N and fat) were altered, the avg. for the chloride space was found to be 25.0% (p.e. [plus or minus] 1.7) and for the histological extracellular space 24.2% (p.e. [plus or minus] 1.3). The evidence supported the view that hepatic cells were normally free of chloride and might be impermeable to it.

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