Synthesis of optically pure Cα‐methyl‐arginine
- 1 August 1992
- journal article
- Published by Wiley in International Journal of Peptide and Protein Research
- Vol. 40 (2) , 119-126
- https://doi.org/10.1111/j.1399-3011.1992.tb01459.x
Abstract
Optically pure L‐(+)‐Cα‐methyl‐arginine and D‐(‐)‐C α‐methyl‐arginine were synthesized. Experimental results indicated that DL‐ Cα‐methyl‐arginine methyl ester could be resolved by trypsin, but workup posed a technical difficulty. Chemical resolution at the stage of DL‐Cα‐methyl‐ornithine, followed by selective guanid‐ination using N,N′‐di‐Cbz‐S‐methylisothiourea and hydrogenolysis provided a effective and practical method for the synthesis of optically pure Cα‐methyl‐arginine.Keywords
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