Recognition of HLA‐A3 and HLA‐A11 by KIR3DL2 is peptide‐specific
Top Cited Papers
Open Access
- 18 May 2004
- journal article
- research article
- Published by Wiley in European Journal of Immunology
- Vol. 34 (6) , 1673-1679
- https://doi.org/10.1002/eji.200425089
Abstract
The recognition of MHC class I molecules by killer cell immunoglobulin‐like receptors (KIR) is central to the control of NK cell function and can also modulate the CTL activation threshold. Among KIR receptors, KIR3DL2 is thought to interact with HLA‐A3 and ‐A11, although direct evidence has been lacking. In this study, we show that HLA‐A3 and ‐A11 tetramers specifically bind to KIR3DL2*001 transfectants and that this recognition is peptide‐specific. Single amino acid substitutions in the nonamer peptide underline a critical role for residue 8 in recognition of KIR3DL2. However, the role of this interaction in vivo still remains to be established.Keywords
This publication has 26 references indexed in Scilit:
- Cell‐surface expression and immune receptor recognition of HLA–B27 homodimersArthritis & Rheumatism, 2002
- Killer cell immunoglobulin‐like receptor expression delineates in situ Sézary syndrome lymphocytesThe Journal of Pathology, 2002
- The D0 Domain of KIR3D Acts as a Major Histocompatibility Complex Class I Binding EnhancerThe Journal of Experimental Medicine, 2002
- Dendritic and Natural Killer Cells Cooperate in the Control/Switch of Innate ImmunityThe Journal of Experimental Medicine, 2002
- Phenotypic Analysis of Antigen-Specific T LymphocytesScience, 1996
- Practical, biochemical and evolutionary implications of the discovery of HLA class I supermotifsImmunology Today, 1996
- Class I major histocompatibility complex-restricted cytotoxic T lymphocytes specific for Epstein-Barr virus (EBV)-transformed B lymphoblastoid cell lines against which they were raised.The Journal of Experimental Medicine, 1995
- Peptide Specificity in the Recognition of MHC Class I by Natural Killer Cell ClonesScience, 1995
- Endogenous peptides bound to HLA-A3 possess a specific combination of anchor residues that permit identification of potential antigenic peptides.Proceedings of the National Academy of Sciences, 1993
- A 72-kD B cell-associated surface glycoprotein expressed at high levels in hairy cell leukaemia and plasma cell neoplasmsClinical and Experimental Immunology, 1991