Skeletal muscle UCP2 and UCP3 gene expression in a rat cancer cachexia model
- 9 October 1998
- journal article
- Published by Wiley in FEBS Letters
- Vol. 436 (3) , 415-418
- https://doi.org/10.1016/s0014-5793(98)01178-8
Abstract
Rats bearing the Yoshida AH-130 ascites hepatoma showed an increased expression of both uncoupling protein-2 (UCP2) (194%) and UCP3 (189%) mRNA levels in skeletal muscle 7 days after tumour inoculation. Interestingly, an even greater increase was observed in mRNA for both UCP2 (278%) and UCP3 (797%) in the pair-fed animals, suggesting that the increase in gene expression was the result of the anorexia associated with tumour burden. The results constitute the first report of UCP2 and UCP3 gene expression during cancer cachexia and agree to their possible role in the increase of energy expenditure associated with tumour growth.Keywords
This publication has 25 references indexed in Scilit:
- Regulation of the Third Member of the Uncoupling Protein Family, UCP3, by Cold and Thyroid HormoneBiochemical and Biophysical Research Communications, 1997
- Uncoupling Protein-3 Is a Mediator of Thermogenesis Regulated by Thyroid Hormone, β3-Adrenergic Agonists, and LeptinJournal of Biological Chemistry, 1997
- Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemiaNature Genetics, 1997
- Stimulation of brown adipose tissue activity in tumor-bearing ratsCanadian Journal of Physiology and Pharmacology, 1995
- Muscle protein waste in tumor-bearing rats is effectively antagonized by a beta 2-adrenergic agonist (clenbuterol). Role of the ATP-ubiquitin-dependent proteolytic pathway.Journal of Clinical Investigation, 1995
- Ubiquitin gene expression is increased in skeletal muscle of tumour‐bearing ratsFEBS Letters, 1994
- Tumor necrosis factor-alpha mediates changes in tissue protein turnover in a rat cancer cachexia model.Journal of Clinical Investigation, 1993
- Increased Brown Adipose Tissue Activity in Children with Malignant DiseaseHormone and Metabolic Research, 1989
- Close Association of Accelerated Rates of Whole Body Protein Turnover (Synthesis and Breakdown) and Energy Expenditure in Children with Newly Diagnosed Acute Lymphocytic LeukemiaJournal of Parenteral and Enteral Nutrition, 1987
- Metabolic Approaches to Cancer CachexiaAnnual Review of Nutrition, 1982