Gastric secretion in unanesthetized chickens

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Abstract
Gastric secretion was collected from 11 unanesthetized White Leghorn chickens under fasting conditions. The basal gastric secretory volume was 15. 4 ml/hr. acid concentration of 93 mEq/liter, and pepsin concentration of 247 PU/ml (Hb substrate method). Subcutaneous histamine (4 mg/kg base) increased gastric secretion to 40 ml/hr, with acid and pepsin concentration, respectively, of 145 mEq/liter and 210 PU/ml. Insulin at 4 and 8 U/kg inhibited confident gastric secretory volume and acid concentration, whereas pepsin output was not significantly altered from control. Fat injection directly into the duodenum through a duodenal fistula did not alter the basal gastric secretory pattern. A comparison of the gastric secretion of the chicken to man, dog, rat, and monkey reveals that the chicken secretes considerably more acid and pepsin in the basal state and following histamine (on a weight basis) than secreted by those mammals listed above.

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