A TURBIDIMETRIC METHOD FOR THE ASSAY OF ANTIBIOTICS

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Abstract
This method was evolved in order to estimate rapidly and accurately the antibacterial activity of new antibiotics present in fermentation, fractionation, product, and clinical samples. By use of a young actively growing culture, the incubation period can be reduced to 3-4 hrs. The activity of an unknown antibiotic is expressed as the dilution of the sample that causes a 50% inhibition of growth of each test culture. The activity of a known antibiotic, such as chloramphenicol, is obtained with the aid of a standard curve and is expressed as the concn. of the antibiotic in the sample.
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