Relationship between Behavioral Changes and Brain Gholinesterase Activity Following Graded Intracerebral Injections of DFP

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Abstract
Intracerebral injections of diisopropylfluoro-phosphate (DFP) in doses less than 0.01 mg into the right caudate nucleus of rabbits had no observable behavioral effect and did not lower the cholinesterase (ChE) activity of that structure to less than 40% of control. Doses of from 0.01 to 0.16 mg, however, produced persistent contraversive forced circus movements and decreased the ChE activity of the right nucleus caudatus from 21 to 40% of control. There was no significant spread of the DFP within the brain in these animals. Increasing further the dose resulted in a progressive intracerebral spread of DFP until eventually only transient circling or death resulted.