Apparent discontinuation rates in patients prescribed lipid‐lowering drugs

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Abstract
Objective: To evaluate apparent discontinuation rates in patients newly prescribed lipid‐lowering drugs. Design and setting: A prospective survey of 12 months' dispensing data in 138 community pharmacies across metropolitan Sydney. Patients: 610 adults (49% men) with a mean age of 58 years; 91 % of prescriptions were from general practitioners; prescribed drugs were simvastatin (54%), pravastatin (31%) and gemfibrozil (15%). Main outcome measure: The number of patients failing to collect prescription refills. Results: 60% of patients (95% confidence interval [CI], 56%–64%) apparently discontinued their medication over 12 months. Half of the apparent discontinuations occurred within three months and a quarter within one month of starting treatment. The predominant reasons for discontinuation were: patient unconvinced about need for treatment (32%), poor efficacy (32%) and adverse events (7%). Only half of those experiencing poor efficacy were switched to another drug. The relative risk (RR) of discontinuation was lower in older patients (age 65+ v. Conclusions: High apparent discontinuation rates with lipid‐lowering drugs suggest significant wastage of resources in treatments that are initiated but not continued and a lost opportunity for heart disease prevention. Many patients appear to discontinue therapy for illogical reasons and this may be amenable to intervention.