Dissociation of a glucan fraction (CO-1) from protein-bound polysaccharide of Cordyceps ophioglossoides and analysis of its antitumor effect.

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Abstract
A glucan moiety (CO-1) was dissociated from the antitumor protein-bound polysaccharide (SN-C) obtained from the culture of Cordyceps ophioglossoides by ultrasonication and heat treatment. CO-1 exhibited antitumor activity against murine sarcoma 180 when given by oral administration. CO-1 was also effective against syngeneic MM46 mammary carcinoma (solid form), but did not show any effect on ascitic tumors such as P388 leukemia. On intraperitoneal administration to normal mice, CO-1 increased the number of peritoneal exudate cells and strongly enhanced the chemiluminescence response of these exudate cells. The activity of CO-1 was higher than that of zymosan-A.