Preparation of potentially bioactive aza and thiaza polycyclic compounds containing a bridgehead nitrogen atom. Synthesis of pyrrolo[1,2,3‐de]‐1,4‐benzothiazine derivatives
- 1 September 1990
- journal article
- research article
- Published by Wiley in Journal of Heterocyclic Chemistry
- Vol. 27 (6) , 1521-1525
- https://doi.org/10.1002/jhet.5570270601
Abstract
The synthesis of some pyrrolo[1,2,3‐de]‐1,4‐benzothiazine derivatives by using a modified Bischler type cyclization of N‐(2,2‐diethoxyethyl)‐2H‐1,4‐benzothiazines as a crucial step is described. The alternative approach based on Friedel‐Crafts alkylation of the N‐(2‐chloroethyl)‐2H‐1,4‐benzothiazines is shown to be impractical due to the low yield obtained.Keywords
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