MD-2 binds to bacterial lipopolysaccharide
Open Access
- 1 December 2000
- journal article
- other
- Published by SAGE Publications in Innate Immunity
- Vol. 6 (6) , 489-491
- https://doi.org/10.1177/09680519000060060201
Abstract
Many LPS binding proteins have been described, but the exact nature of the LPS receptors that signal cells remains unclear. MD-2 is a molecule that is found in association with Toll-like receptor 4, which has been shown to be a receptor for LPS. We have produced human MD-2 in baculovirus and tested it for LPS binding. MD-2 binds the lipid A region of LPS without the need for LPS binding protein. These data suggest that MD-2 may be binding LPS as part of the TLR4 receptor complex.Keywords
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