Lipid Fatty Acid Composition of Several Areas of the Aorta in Subjects with Atherosclerosis.

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Abstract
The cholesterol ester, triglyceride and phospholipid fatty acid composition (gas-liquid chromatography) of aortic media, thickened intima and plaque material were determined in 6 human subjects. For comparison, the fatty acid composition of those fractions in serum was determined in 6 subjects (aged 55-70 years) with occlusive atherosclerosis in a good nutritional status. The triglyceride fraction of those tissues and serum were similar in their fatty acid composition. Some slight differences were noted in the fatty acid composition of the phospholipid fractions, most notably in the arachidonic and long chain fatty acids. The cholesterol ester fraction of the tissues studied showed the greatest differences in fatty acid composition. Both early and advanced plaques had significantly less linoleic and more oleic acid in that fraction than serum or media. Media and serum CEFA were similar in their fatty acid composition. The significance of these findings in relation to atherogenesis is discussed.