Regulation of Integrin-Dependent Release in Human Lung Mast Cells and Basophils
- 1 January 1995
- journal article
- development and-function-of-effector-cells
- Published by S. Karger AG in International Archives of Allergy and Immunology
- Vol. 107 (1-3) , 151-153
- https://doi.org/10.1159/000236960
Abstract
The interaction of cells with surfaces or components of the extracellular matrix alters cell responses and is regulated by integrins on the cell surface. We have used monoclonal antibodies to CD29 and CD49d followed by an F(ab)2 fragment of rabbit anti-mouse IgG1 to cross-link the integrins on the surface of human lung mast cells and basophils. We found that cross-linking either CD29 or CD49d failed to initiate mediator release from the basophils of non-atopic and atopic donors [histamine release (HR) = 1 ± 0.5% for CD29 and 1 ± 0.5% for CD49d, n= 10, NS]. In contrast we found that clustering CD29 caused significant HR from the basophils of asthmatic donors (HR = 21 ± 5%, n = 10, pKeywords
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