ACETYLASPARTIC ACID AND AMMONIA POISONING
- 1 January 1960
- journal article
- Published by Canadian Science Publishing in Canadian Journal of Biochemistry and Physiology
- Vol. 38 (1) , 763-768
- https://doi.org/10.1139/y60-093
Abstract
Acetylaspartic acid has been followed in nine tissues of normal and ammonia-poisoned rats. This acetylated amino acid is present at high concentrations in normal brain and remains unchanged in ammonia-poisoned brain. Acetylaspartic acid is absent or present in trace amounts in normal liver. It increases appreciably in ammonium acetate poisoning, reaching a peak at death. No change in concentration was detectable in the other tissues examined. There is a correlation between aspartic and acetylaspartic acid in the liver. But no correlation was observed between acetylaspartic acid on the one hand and ammonia and urea on the other. The possible origins of acetylaspartic acid are discussed.Keywords
This publication has 2 references indexed in Scilit:
- Studies on the metabolism of amino acids and related compounds in vivo. VI. Free amino acid levels in the tissues of rats protected against ammonia toxicityArchives of Biochemistry and Biophysics, 1957
- Studies on the metabolism of amino acids and related compounds in vivo. V. Effects of combined administration of nonprotective compounds and subprotective levels of l-arginine.HCL on ammonia toxicity in ratsArchives of Biochemistry and Biophysics, 1956