Slow Orthograde Axonal Transport of Radiolabelled Protein in Sciatic Motoneurones of Rats with Short‐Term Experimental Diabetes: Effects of Treatment with an Aldose Reductase Inhibitor or myo‐Inositol

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Abstract
The effect of streptozotocin diabetes of 5 wk duration on the profile of slow orthogradely transported radiolabeled protein in rat sciatic motoneurons was examined. The diabetic rats showed a retardation of the tail of the slow-component profile. This selective retardation was unaffected by treatment with an aldose reductase inhibitor, although this treatment reduced the accumulation of sorbitol and prevented the depletion of myo-inositol in the sciatic nerves of the treated diabetic rats. Other groups, treated with myo-inositol, had normal or elevated sciatic nerve myo-inositol levels in the presence of accumulated sorbitol. The axonal transport profiles from both control and diabetic myo-inositol-treated groups gave normal tail velocities but an altered shape such that retardation of the tail of the profile may have been present in both. Rats with 5 wk streptozotocin diabetes show retardation of the velocity of the most slowly transported proteins in sciatic motoneurons, and this defect is not linked to the polyol pathway.

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