Fibroblast function and the maintenance of the aortic-valve matrix
- 1 March 1979
- journal article
- research article
- Published by Oxford University Press (OUP) in Cardiovascular Research
- Vol. 13 (3) , 167-172
- https://doi.org/10.1093/cvr/13.3.167
Abstract
The long-term behaviour of the aortic-valve allograft seems to be dependent on the maintenance of its matrix. Protein and collagen synthesis was studied in rat aortic-valves. Quantitative and qualitative methods proved the production of at least two protein pools. One protein pool is localised intracellularily with a 'turn-over' time of about 2 weeks, and a second pool is localised extracellularily with a 'turn-over' time of at least 8 weeks. The latter protein pool mainly consists of collagen.Keywords
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