Synthesis of a thymosin .BETA.4-like peptide, deacetyl-thymosin .BETA.4Xen, and its restorative effect on depressed lymphocyte blastogenic response to phytohemagglutinin(PHA) in uremic patients.

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Abstract
An analog of thymosin .beta.4Xen isolated from oocytes of Xenopus laevis, deacetyl-thymosin .beta.4Xen, was synthesized by assembling 6 peptide fragments, followed by deprotection with 1 M trifluoromethanesulfonic acid-thioanisole (molar ratio, 1:1) in trifluoroacetic acid in the presence of dimethylselenium. Finally, the deprotected peptide was incubated with dithiothreitol to reduce sulfoxide on the methionine side chain. The synthetic tritetracontapeptide was found to have a restoring effect on the impaired blastogenic response of T-lymphocytes isolated from uremic patients.

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