RANDOMIZED CONTROLLED TRIAL OF HAND-ASSISTED LAPAROSCOPIC VERSUS OPEN SURGICAL LIVE DONOR NEPHRECTOMY1

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Abstract
Laparoscopic live donor nephrectomy for renal transplantation is being performed in increasing numbers with the goals of broadening organ supply while minimizing pain and duration of convalescence for donors. Relative advantages in terms of recovery provided by laparoscopy over standard open surgery have not been rigorously assessed. We hypothesized that laparoscopic as compared with open surgical live donor nephrectomy provides briefer, less intense, and more complete convalescence. Of 105 volunteer, adult, potential living-renal donors interested in the laparoscopic approach, 70 were randomly assigned to undergo either hand-assisted laparoscopic or open surgical live donor nephrectomy at a single referral center. Objective data and subjective recovery information obtained with telephone interviews and validated questionnaires administered 2 weeks, 6 weeks, and 6–12 months postoperatively were compared between the 23 laparoscopic and 27 open surgical patients. There was 47% less analgesic use (P =0.004), 35% shorter hospital stay (P =0.0001), 33% more rapid return to nonstrenuous activity (P =0.006), 23% sooner return to work (P =0.037), and 73% less pain 6 weeks postoperatively (P =0.004) in the laparoscopy group. Laparoscopic patients experienced complete recovery sooner (P =0.032) and had fewer long-term residual effects (P =0.0015). Laparoscopic donor nephrectomy is associated with a briefer, less intense, and more complete convalescence compared with the open surgical approach.