Effect of Norepinephrine on Myocardial Free Fatty Acid Uptake and Oxidation,

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Abstract
Summary An intravenous infusion of labeled palmitic acid was repeated after an interval of about 90 minutes on the same intact anesthetized dog. During the second period, an infusion of NE (0.2 or 0.4 μg/kg/min) was also given. Arterial FFA, CS-A difference for FFA and myocardial uptake of FFA were increased by the higher dose of XK; the specific activity of arterial FFA, the extraction ratio of FFA and myocardial R.Q. were decreased. Infusion of nicotinic acid, preceding administration of NE eliminated the above changes. It appears that myocardial FFA oxidation is indirectly influenced. by NE, through FFA mobilization and the elevated arterial level of this metabolite.