The Use of Intravenous Chlorimipramine in the Treatment of Obsessive Compulsive Disorder*
- 1 March 1984
- journal article
- case report
- Published by SAGE Publications in The Canadian Journal of Psychiatry
- Vol. 29 (2) , 135-141
- https://doi.org/10.1177/070674378402900211
Abstract
Obsessional disorder has always remained a difficult illness for psychiatrists to treat with response to therapy, both psychotherapy and chemotherapy, being low. A review of the traditional approaches to the treatment of obsessional disorder is done, including a brief review of the literature on intravenous chlorimipramine. Five case histories of patients with previously non-responsive obsessional disorder are summarized. All five cases were treated in hospital with a series of infusions of intravenous chlorimipramine. The drug and route of administration was extremely well tolerated with rapid and dramatic relief of obsessional symptoms as well as improvement of mood in all cases. The theoretical action of chlorimipramine is discussed as well as possible reasons why the intravenous route appears to be superior to the oral form.Keywords
This publication has 20 references indexed in Scilit:
- Recent Advances in the Behavioral Treatment of Obsessive-CompulsivesArchives of General Psychiatry, 1982
- Review of behavioral psychotherapy, I: Obsessive-compulsive disordersAmerican Journal of Psychiatry, 1981
- Clomipramine Treatment of Obsessive-Compulsive DisorderArchives of General Psychiatry, 1980
- Monoamine metabolites in cerebrospinal fluid and serotonin uptake inhibition during treatment with chlorimipramineClinical Pharmacology & Therapeutics, 1977
- Treatment of Chronic Obsessive-Compulsive Neurosis by in-vivo ExposureThe British Journal of Psychiatry, 1975
- Clomipramine (Anafranil) in the Treatment of Obsessional States with Special Reference to the Leyton Obsessional InventoryJournal of International Medical Research, 1973
- Modified Leucotomy Assessed Clinically, Physiologically and Psychologically at Six Weeks and Eighteen MonthsThe British Journal of Psychiatry, 1972
- Chlorimipramine in Obsessional States: A Pilot StudyPsychosomatics, 1971
- Effect of antidepressant drugs on the depletion of intraneuronal brain 5-hydroxytryptamine stores caused by 4-methyl-α-ethyl-meta-tyramineEuropean Journal of Pharmacology, 1969
- Follow-Up Studies in Obsessional NeurosisArchives of General Psychiatry, 1969