Use of Second Derivative Spectrophotometry For the Determination of Certain Cephalosporins and Their Acid-Induced Degradation Products In Combination
- 1 January 1989
- journal article
- pharmaceutical analysis
- Published by Taylor & Francis in Analytical Letters
- Vol. 22 (1) , 159-175
- https://doi.org/10.1080/00032718908051191
Abstract
Methods for determination of individual cephalosporins and their corresponding acid-induced degradation products are described, based upon second derivative spectrophotometry. Linear plots of D2[dbnd](d2A/dλ2) values with negligible intercept were obtained versus concentration in the range of 0.4–2.4 mg% for both intact and degraded cephalosporins. Kinetic investigation of the cephalosporins degradation proved that the proposed method is applicable to stability determinations Compared with the official method the assay results of the different cephaiosporins pharmaceutical preparations were of equal accuracy (t-test) and reproducibility (F-test).Keywords
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