Cell-Mediated Immunity in Halothane Hypersensitivity

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Abstract
CLINICAL data accumulated over the past 10 years leave no doubt that postoperative hepatic necrosis may result from halothane anesthesia in predisposed persons. Drug reactions to this otherwise entirely satisfactory anesthetic occur in about 1:10,000 subjects, but fatal cases amount to no more than 1:800,000 anesthetics. Clinical pointers to drug hypersensitivity, such as leukocytosis with eosinophilia, joint pains, rashes and bronchospasm upon inhalation of the drug, are found after halothane, and in two cases abnormal lymphocytes similar to those seen in infectious mononucleosis have been noted in the peripheral blood. The more regular features are unexplained fever with chills, sometimes . . .

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