The NorR Protein of Escherichia coli Activates Expression of the Flavorubredoxin Gene norV in Response to Reactive Nitrogen Species
Open Access
- 15 August 2002
- journal article
- Published by American Society for Microbiology in Journal of Bacteriology
- Vol. 184 (16) , 4640-4643
- https://doi.org/10.1128/jb.184.16.4640-4643.2002
Abstract
The Escherichia coli norVW genes encode a flavorubredoxin and NADH:(flavo)rubredoxin reductase, respectively, which are involved in nitric oxide detoxification under anaerobic growth conditions. Here it is shown that the norVW genes also have a role in protection against reactive nitrogen intermediates generated from nitroprusside. Transcription from the norV promoter is activated by the presence of nitroprusside in the growth medium; activation requires the product of a divergently transcribed regulatory gene, norR.Keywords
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