In Vitro Effect of Estrogens on the Peroxidase Activity of Human Endometrium*

Publisher Website
Google Scholar
Abstract
The effect of estrogen on the induction of human endometrial peroxidase was studied in vitro. When 17β-estradiol was added to the incubation medium, endometrial peroxidase activity was markedly increased, and the highest enzymatic activities were reached at about 12 h of incubation. The ability of estrogen and related compounds to increase peroxidase activity at a concentration of 10−7 M was 17β-estradiol > estrone > 17α-ethynylestradiol > estriol = diethylstilbestrol. Mestranol, progesterone, and testosterone had almost no activity. The induction of peroxidase by 17β-estradiol was inhibited by actino-mycin D or cycloheximide. This method may be useful for determining the direct estrogenic effect of compounds in human endometrium.

This publication has 5 references indexed in Scilit: