Properties of the phosphonomethyl isosteres of two phosphate ester glycolytic intermediates
- 1 September 1974
- journal article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 141 (3) , 725-728
- https://doi.org/10.1042/bj1410725
Abstract
The enzymic synthesis of the 1-phosphonomethyl isostere of fructose 1,6-diphosphate in which the 1-phosphate (–OPO3H2) is replaced by the phosphonomethyl group (–CH2PO3H2) is described. The kinetic properties of this fructose diphosphate isostere and of 4-hydroxy-3-oxobutylphosphonic acid, an isostere of dihydroxyacetone phosphate, with aldolase (EC 4.1.2.13), fructose diphosphatase (EC 3.1.3.11) and glycerol phosphate dehydrogenase (EC 1.1.1.8) are described (see Table 1).Keywords
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