Left Ventricular Receptors Inhibit Brain Serotonin Neurons During Coronary Artery Occlusion

18 August 1978

journal article
research article
Published by American Association for the Advancement of Science (AAAS) in Science

Vol. 201 (4356) , 620-622
https://doi.org/10.1126/science.675245

Abstract

Acute coronary artery ligation in pargyline-treated rats decreased serotonin and increased 5-hydroxyindoleacetic acid in the medulla and posterior hypothalamus. Lidocaine applied topically to the left ventricle completely prevented these alterations. No changes in serotonin were observed in the other brain regions examined. These data suggest a reflex inhibition of bulbar and hypothalamic serotonergic nerves by left ventricular receptors following acute coronary artery occlusion in the rat.

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