LETHAL EFFECT OF ACLACINOMYCIN A ON CULTURED MOUSE L-CELLS

  • 1 January 1980
    • journal article
    • research article
    • Vol. 71  (5) , 699-703
Abstract
The effect of aclacinomycin A on the survival of cultured mouse [neoplastic fibroblast] L cells was studied. The drug showed a characteristic dose-survival response, i.e., an initial exponential response followed by a sigmoidal inactivation characterized by a broad shoulder. With prolongation of the exposure time, the exponential response seen at a low concentration was remarkably intensified with a progressive decrease of the shoulder width. Two-dose fractional survival studies revealed that at least a portion of the shoulder region related to an accumulation of sublethal damage which can be repaired during 12 h after the 1st dose. The implication of these results for therapeutic scheduling is discussed.