In vivo Behaviour of Neuraminidase-Treated Rabbit Erythrocytes and Reticulocytes

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Abstract
51Cr rabbit erythrocytes were treated with different amounts of neuraminidase and reinjected into the animal. The survival curves after the removal of more than 5θ% membrane sialic acid show a characteristic behaviour: after a rapid decrease, blood radioactivity increases again reaching a maximum level 50–80 h after reinjection, then tends to decrease with a slope similar to that of control curves. Liver radioactivity determined before the rise of blood radioactivity is evidently higher than the value determined after radioactivity elevation. Similar results were obtained with phenylhydrazine-induced young erythrocytes.