Association of l‐tryptophan and an illness resembling eosinophilic fasciitis: clinical and histopathologic findings in four patients with eosinophilia‐myalgia syndrome

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Abstract
The Centers for Disease Control has recently reported an association between the use of oral L‐tryptophan preparations and a disease marked by severe myalgia, peripheral eosinophilia, and neuromuscular and cutaneous abnormalities. They have labeled the condition eosinophilia‐myalgia syndrome. We report here the clinical and histopathologic findings in 4 patients who developed an illness resembling eosinophilic fasciitis following the initiation of oral L‐tryptophan supplementation.