Should Thrombolysis or Primary Angioplasty Be the Treatment of Choice for Acute Myocardial Infarction?
- 24 October 1996
- journal article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 335 (17) , 1311-1312
- https://doi.org/10.1056/nejm199610243351710
Abstract
In the past 20 years, pathological and arteriographic studies have shown that Q-wave myocardial infarction is caused by an occlusive thrombus in a coronary artery. The primary therapeutic objective in a patient with an evolving Q-wave myocardial infarction is the prompt restoration of antegrade flow in the occluded artery. Since both immediate (so-called primary) coronary angioplasty and thrombolysis can restore antegrade flow in most occluded coronary arteries, there is disagreement about which approach is better for evolving infarction.In placebo-controlled, randomized trials involving almost 60,000 patients, thrombolytic therapy has been shown to limit infarct size, improve left ventricular function, and . . .Keywords
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