Hippocampal dendritic abnormalities in a rat model of phenylketonuria
- 1 November 1984
- journal article
- research article
- Published by Wiley in Annals of Neurology
- Vol. 16 (5) , 577-580
- https://doi.org/10.1002/ana.410160508
Abstract
An increased concentration of dendritic spines was present in one region of the hippocampus in rats made hyperphenylalaninemic (phenylketonuria model). It is uncertain whether this finding resulted from an actual hyperplasia or a failure of maturational spine reduction. The result is unusual in that Golgi studies of most mental retardation syndromes and relevant animal models have shown loss of dendritic spines.This publication has 13 references indexed in Scilit:
- Effects of Untreated Maternal Phenylketonuria and Hyperphenylalaninemia on the FetusNew England Journal of Medicine, 1983
- Axonal ramifications of hippocampal Ca1 pyramidal cellsJournal of Neuroscience, 1981
- Influence of extrauterine survival on branching characteristics of hippocampal neurons in preterm infantsExperimental Neurology, 1981
- Development of afferent lamination in Ammon's horn of the ratBrain Structure and Function, 1980
- Myelin Deficiency in Experimental Phenylketonuria: Contribution of the Aromatic Acid Metabolites of PhenylalaninePublished by Springer Nature ,1978
- Pyramidal cell abnormalities in the motor cortex of a child with Down's syndrome. A Golgi studyJournal of Comparative Neurology, 1976
- Normal and Aberrant Neuronal Development in the Cerebral Cortex of Human Fetus and Young InfantPublished by Elsevier ,1975
- Dendritic development in neocortex of children with mental defect and infantile spasmsNeurology, 1974
- Structural organization of the cerebral cortex (motor area) in human chromosomal aberrations. A golgi study. I. D1 (13–15) trisomy, patau syndromeBrain Research, 1974
- Neuropathology of PhenylketonuriaJournal of Neuropathology and Experimental Neurology, 1966