l-Leucine Sensitivity and Glucose Tolerance in Normal Subjects1

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Abstract
The response of the blood glucose to l-leucine was compared with control observations in each of 20 normal subjects. l-Leucine exerted an over-all hypoglycemic effect regardless of whether data were analyzed in terms of 1) the area between control and experimental curves, 2) the percentage difference between control and experimental curves at the time of maximal fall in blood glucose or 3) the percentage difference from base-line values of control and experimental values for all samples obtained between 30 and 100 min following l-leucine ingestion. In addition, a significant correlation was found between l-leucine sensitivity and glucose tolerance in this normal population. The possibility that such a correlation is part of a spectrum extending to both diabetes mellitus and hyperinsulinism is discussed.