A PRELIMINARY STUDY OF THE ANTIGENIC ACTIVITY OF MIXTURES OF CLOSTRIDIUM BOTULINUM TOXOID TYPES A AND B

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Abstract
When Types A and B Clostridium botulinum toxoids were mixed the resultant divalent toxoid was found to have a very high protective potency against both Type A and Type B botulinus toxin. The resistance to Type A toxin induced in guinea-pigs and mice by the divalent toxoid mixture was only slightly less than that conferred by a similar volume of univalent Type A toxoid. Guinea-pigs given the divalent toxoid developed a comparable or slightly higher degree of immunity to Type B toxin than those injected with univalent Type B toxoid.Although no evidence of reciprocal protection had been observed between Type A and Type B toxoids, admixture with Type A toxoid appreciably increased the antigenicity of the Type B toxoid for mice. Mice immunized with the divalent, A + B, toxoid exhibited a higher level of resistance to Type B toxin than those given the same number of doses of Type B toxoid alone. No adjuvant effect was noted on mixing Type A or Type B botulinus toxoids with tetanus or diphtheria toxoids.

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