Bacteriological studies with cefsulodin (CGP 7174/E), the first antipseadomonal cephalosporin

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Abstract
The new cephalosporin, cefsulodin, has considerable anti-bacterial activity against Pseudomonas aeruginosa. When 217 strains of P. aeruginosa were tested against azlocillin and cefsulodin, 26.3% had the same minimal inhibitory concentration (MIC); the MIC for azlocillin was lower than that for cefsulodin in 16.6% of strains but higher in 57.1%. A total of 22 gentamicin-resistant strains were all susceptible to cefsulodin. Biophotometer investigations demonstrate less bactericidal effects for cefsulodin and azlocillin than for carbenicillin and ticarcillin using higher inocula than used in the agar of tube dilution test. Cefsulodin and gentamicin are synergistic against P. aeruginosa. Using high pressure liquid chromatography and biological techniques, cefsulodin is moderately stable in solution and in standard solid laboratory media.

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