Therapeutic Benefits from Targeting of ADAM Family Members
- 21 May 2004
- journal article
- review article
- Published by American Chemical Society (ACS) in Biochemistry
- Vol. 43 (23) , 7227-7235
- https://doi.org/10.1021/bi049677f
Abstract
Members of the ADAM (a disintegrin and metalloproteinase) family of proteolytic enzymes are implicated in the processing of many single transmembrane-bound proteins ranging from cell surface receptors to growth factors and cytokines. Because of the biological significance of these processing events, a recurring theme in studying ADAM biology is that they are involved in physiological processes that can go awry and lead to disease states. This review provides a comprehensive look at ADAM family members and their role in pathology and provides a pathway for determining whether an enzyme is a physiological convertase for a given protein. In addition, ADAMs are discussed as potential therapeutic targets.Keywords
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