Impaired drinking responses of rats with lesions of the subfornical organ.

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Abstract
Electrolytic lesions of the subfornical organ (SFO) in rats abolish their drinking response to i.v. infusion of angiotensin II (AII). Such lesions also attenuate drinking after 20% polyethylene glycol solution (PEG) is given s.c., which suggests that AII may play an important role in mediating thirst during hypovolemia. Such rats with SFO lesions may drink normal amounts when larger plasma volume deficits are caused by 30% PEG treatment. They also may drink normal amounts in response to 20% PEG when pretreated either with caffeine or hypertonic NaCl solution. They may not drink in response to relatively low doses of hypertonic saline but drink normal amounts when given larger doses. The SFO is apparently involved in a control system for thirst and after damage to it greater stimulation than usual may be required for drinking to be initiated. From this perspective, drinking would be expected following either suprathreshold stimulation or drug-induced lowering of the activation threshold in these animals, as was observed, with the loss of putative AII receptors in the SFO also contributing to their particularly severe deficits in thirst induced by AII.