Free radicals imaged in vivo in the rat by using proton-electron double-resonance imaging
- 15 December 1990
- journal article
- Published by The Royal Society in Philosophical Transactions A
- Vol. 333 (1632) , 453-456
- https://doi.org/10.1098/rsta.1990.0172
Abstract
A new technique called proton—electron double-resonance imaging is described for imaging free radicals in aqueous samples. The method is a combination of proton NMR imaging with nuclear electron double resonance. The results of using this technique to image free radicals in vivo in the rat are presented. Rats were injected intravenously with a nitroxide free radical solution and a series of images was obtained from which the clearance of the free radical through the liver and kidneys could be observed.Keywords
This publication has 8 references indexed in Scilit:
- In vivo detection of injected free radicals by overhauser effect imagingMagnetic Resonance in Medicine, 1990
- Direct measurement of free radical generation following reperfusion of ischemic myocardium.Proceedings of the National Academy of Sciences, 1987
- ESR Imaging and Its ApplicationsApplied Spectroscopy Reviews, 1986
- Enhanced MRI of tumors utilizing a new nitroxyl spin label contrast agentMagnetic Resonance Imaging, 1985
- Measurement of intracellular oxygen concentration using the spin label TEMPOLMagnetic Resonance in Medicine, 1985
- Free-radical mechanisms in tissue injuryBiochemical Journal, 1984
- In vivo n.m.r. imaging in medicine: the Aberdeen approach, both physical and biologicalPhilosophical Transactions of the Royal Society of London. B, Biological Sciences, 1980
- Nuclear Electron Double Resonance in LiquidsPublished by Elsevier ,1969