THE RESPIRATORY QUOTIENT AND EXCITABILITY OF FROG MUSCLE TREATED WITH IODOACETATE AND IODOACETAMIDE

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Abstract
The R.Q. of resting intact frog muscle whose glycolysis had been completely inhibited by 0.32 X 10-3 molar iodoacetate was 0.91; sufficiently like that of unpoisoned muscle to be considered identical. Muscles similarly treated with iodoacetamide exhibited a R.Q. of unity. In neither case was the oxidation of carbohydrate impaired by the cessation of lactate formation. Preformed lactate could not account for the oxidation. Iodoacetate first increases then decreases the a excitability of frog muscle. The decrease accompanies the onset of rigor. In iodoacetamide the phase of increased excitability does not appear; decreasing excitability is similar to that seen in iodoacetate.

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