THE ROLE OF PERIPHERAL LYMPHOCYTES IN THE PREDICTION OF RECURRENCE IN CROHNS-DISEASE

Google Scholar
  • 1 January 1985
    • journal article
    • research article
    • Vol. 160  (4) , 295-298
Abstract
Sixty-five patients with Crohn''s disease admitted for surgical treatments to The Mount Sinai Hospital [New York, USA] were studied prospectively to determine whether or not preoperative peripheral lymphocyte counts correlate with early recurrence; 24 patients had symptomatic recurrent disease develop within 3 yr after operation. Patients who had recurrences were found to have significantly lower preoperative lymphocyte counts than patients doing well 3 yr after surgical resection; 69% of the patients with preoperative lymphocyte counts of < 1,000 cells/mm3 had recurrent disease develop within 3 yr of the operation. In contrast, only 8% of the patients with preoperative lymphocyte counts of > 2,100 cells/mm3 had recurrences. Patients with marked preoperative lymphocytopenia evidently are more likely to develop early symptomatic recurrences after surgical treatmnt than patients with normal lymphocyte counts.