A Sequential Trial Comparing Two Plasma Levels of Nortriptyline

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Abstract
Pairs of depressed patients were matched for age, sex, and severity of depression, and treated for four weeks with nortriptyline so that plasma levels of below 49 ng/ml and above 140 ng/ml were, obtained. Comparisons of pairs of patients as regards to improvement of depression, using a sequential skew restricted design, suggested that it was unlikely that a significant difference between the two treatment regimes would be detected.